Pharmacology.
Leflunomide’s active metabolite (M1) inhibits dihydro-oratate dehydrogenase, thereby inhibiting pyrimidine biosynthesis. M1 exhibits immunomodulating and anti-inflammatory effects.
Administration and Adult Dosage.
PO for rheumatoid arthritis 100 mg/day for 3 days, then 20 mg/day. Reduce dose to 10 mg if 20 mg is not tolerated.
Pediatric Dosage.
Safety and efficacy not established.
Geriatric Dosage.
Same as adult dosage.
Dosage Forms.
Definition
A headache is a pain in the head and neck region that may be either a disorder in its own right or a symptom of an underlying medical condition or disease. The medical term for headache is cephalalgia.
Description
Headaches are divided into two large categories, primary and secondary, according to guidelines established by the International Headache Society (IHS).
Pharmacology:
Acetaminophen possesses analgesic and antipyretic activities with few anti-inflammatory effects. It has the same effectiveness as aspirin in inhibiting brain prostaglandin synthetase but very little activity as a peripheral prostaglandin inhibitor. This difference from aspirin and other NSAIDs might explain its relative lack of effectiveness as an anti-inflammatory, antirheumatic agent. Acetaminophen does not inhibit normal platelet action, prothrombin activity, or adversely affect GI mucosal health.
Administration and Adult Dosage:
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