Acromegaly and Gigantism

Definition

Acromegaly is a disorder in which the abnormal release of a particular chemical from the pituitary gland in the brain causes increased growth in bone and soft tissue, as well as a variety of other disturbances throughout the body. This chemical released from the pituitary gland is called growth hormone (GH). The body’s ability to process and use nutrients like fats and sugars is also altered. In children whose bony growth plates have not closed, the chemical changes of acromegaly result in exceptional growth of long bones. This variant is called gigantism, with the additional bone growth causing unusual height. When the abnormality occurs after bone growth stops, the disorder is called acromegaly.

Angioplasty

onclick="javascript:pageTracker._trackPageview ('/outbound/youtube.com');">Angioplasty Patient Education Video

Definition

Angioplasty is a term describing a procedure used to widen vessels narrowed by stenoses or occlusions. There are various types of angioplasty. The specific names of these procedures are derived from the type of equipment used and the path of entry to the blood vessel. For example, percutaneous transluminal angioplasty (PTA) means that the vessel is entered through the skin (percutaneous) and that the catheter is moved into the blood vessel of interest through the same vessel or one that communicates with it (transluminal). In the case of an angioplasty involving the coronary arteries, the point of entry might be the femoral artery in the groin, with the catheter/ guidewire system passed through the aorta to the heart and the origin of the coronary arteries at the base of the aorta just outside the aortic valve.

The Ab Workout

Hanging oblique curls
Hang from a pull-up bar with your legs bent at a 30-degree angle. Raise your feet until thighs are parallel to the floor. Tense abs and slowly raise your legs until feet are almost as high as your head. Lower your legs to the middle position and rotate them to the right (feet point 2 o’clock), then to the left (feet at 10 o’clock). Bring your legs back to the centre and lower; repeat the entire cycle 3 or 4 times.

Fluoxetene (anti-depressant)

Pharmacology.

Fluoxetine is a bicyclic antidepressant that is a selective and potent inhibitor of presynaptic reuptake of serotonin (an SSRI). It does not affect re-uptake of norepinephrine or dopamine and has a relative lack of affinity for muscarinic, histamine,


1- and


2-adrenergic, and serotonin receptors.

Administration and Adult Dosage.

CYCLOPHOSPHAMIDE

Pharmacology.
Cyclophosphamide is inactive in vitro and must be enzymatically activated in the liver to yield active alkylating compounds and toxic metabolites. Cell-cycle phase nonspecific.

Administration and Adult Dosage.
IV or PO alone or in combination regimens 250-500 mg/m2 q 3-4 weeks. IV (usually) or PO in high-dose intermittent regimens (including bone marrow transplant) maximum of 40-50 mg/kg given once or over 2-5 days, repeat q 2-4 weeks-these doses are not well tolerated orally.

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